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Isolated Linear Discoid Lupus Erythematosus of Scalp Following Lines of Blaschko عبدالرحمن ابراهيم المريشد

Discoid lupus erythematosus (DLE) is an inflammatory autoimmune disease leading to scarring and hair loss. Linear Discoid lupus erythematosus has been mentioned in the literature as a rare variant. This article describes isolated linear DLE of the scalp. We present a 26-year-old Saudi male who had unilateral linear DLE of the scalp with no involvement of other body sites and no systemic manifestations. This case is the first case of isolated linear DLE on the scalp. This presentation should be considered as a differential diagnosis of linear scarring alopecia as a distinct morphological pattern of DLE.

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British Journal of Dermatology ; Role of senescent fibroblasts in the development of idiopathic guttate hypomelanosis. عبدالرحمن ابراهيم المريشد
BACKGROUND:

Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentary disorder occurring mainly on exposed areas in elderly individuals. Long-term sun exposure is thought to be a main cause of IGH but the pathogenesis is still unknown.

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Pigment Cell & Melanoma Research ; Autophagy induction can regulate skin pigmentation by causing melanosome degradation in keratinocytes and melanocytes. عبدالرحمن ابراهيم المريشد

Autophagy regulates cellular turnover by disassembling unnecessary or dysfunctional constituents. Recent studies demonstrated that autophagy and its regulators play a wide variety of roles in melanocyte biology. Activation of autophagy is known to induce melanogenesis and regulate melanosome biogenesis in melanocytes. Also, autophagy induction was reported to regulate physiologic skin color via melanosome degradation, although the downstream effectors are not yet clarified. To determine the role of autophagy as a melanosome degradation machinery, we administered several autophagy inducers in human keratinocytes and melanocytes. Our results showed that the synthetic autophagy inducer PTPD-12 stimulated autophagic flux in human melanocytes and in keratinocytes containing transferred melanosomes. Increased autophagic flux led to melanosome degradation without affecting the expression of MITF. Furthermore, the color of cell pellets of both melanocytes and keratinocytes was visibly lightened. Inhibition of autophagic flux by chloroquine resulted in marked attenuation of PTPD-12-induced melanosome degradation, whereas the expression of melanogenesis pathway genes and proteins remained unaffected. Taken together, our results suggest that the modulation of autophagy can contribute to the regulation of melanocyte biology and skin pigmentation.

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The Journal of Dermatology ; Mixed vitiligo that progressed from segmental inflammatory vitiligo, clinically mimicking lichen striatus. J Dermatol. 2019 Aug 28. https://www.ncbi.nlm.nih.gov/pubmed/31463994. عبدالرحمن ابراهيم المريشد
Mixed vitiligo that progressed from segmental inflammatory vitiligo, clinically mimicking lichen striatus. J Dermatol. 2019 Aug 28. https://www.ncbi.nlm.nih.gov/pubmed/31463994. ...
Extrahepatic Portosystemic Shunt and Intrahepatic Gallbladder: A Case Report عبدالله فهد الفواز
Congenital extrahepatic portosystemic shunt is not that common. However, non-congenital extrahepatic portosystemic shunt can be caused by various etiologies, for instance, post-trauma, surgical intervention and portal hypertension. We’re reporting a case of asymptomatic adult female and the incidental imaging findings related to this condition. ...
Frequent debridement with vacuum assisted closure dressing for severe first metatarsal and metatarsophalangeal joint gouty arthritis as infectious arthritis نايف عبدالله آل نويهض

Introduction

Gout is a common disorder of uric acid metabolism, characterizedby recurrent episodes of inflammatory arthritis, tophaceous soft tissuedeposits of monosodium urate crystals, uric acid renal calculi and chronic nephropathy, I present the case of a 31 year old male patient Known case of Acute renal failure , with history of recurrent renal stone presented with progressive swelling of right big toe suffering from tophaceous gout.

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Venous thromboembolism incidence in unilateral versus bilateral total knee joint replacement نايف عبدالله آل نويهض

Abstract Background:

The commonest joint replacement performed around the world as well as in Prince Sultan Military Medical City (PSMMC) in Riyadh, Saudi Arabia, is total knee joint replacement (TKR). Bilateral TK requires single anesthesia, short hospital stay, single rehabilitation, and is cost-effective. However, some post-TKR risks have been reported

Naif Bin Nwihadh,1 Mohammed Al Harbi,2 Abdulrahman N Shebly,3 Husameldin Osama Bashir,4 Mohammed Ali Al-Ruwaili,3 Abdullah Osamah Mirdad,1 Bashir Alenazi3 1 surgery Department, Prince Sattam bin Abdulaziz University, Saudi Arabia 2 Qassim University, Saudi Arabia 3 Prince Sultan Military Medical City, Saudi Arabia 4 National Ribat University, Saudi Arabia

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A Rare Case of Complex Occult Spinal Dysraphism with Association of Asymptomatic Tethered Cord Syndrome نايف عبدالله آل نويهض

ABSTRACT We present the case of a 62-year-old female housewife who reported non-specific back pain for the past 35 years. Without neurological symptoms, A complex occult spinal dysraphism and a tethered cord syndrome was diagnosed.

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Effectiveness of Exercise Protocols in Treatment of Patellofemoral Pain Syndrome: A Prospective Comparative Study نايف عبدالله آل نويهض

Effectiveness of Exercise Protocols in Treatment of Patellofemoral Pain Syndrome: A Prospective Comparative Study 

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Prevalence of Dyslipidemia in None Diabetic Sudanese Patients with End Stage Renal Disease on Regular Hemodialysis محمد احمد نور الدين محمد احمد
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